In an induced otitis externa study using dogs infected with Malassezia pachydermatis, 1% clotrimazole
Resistance to clotrimazole is very rare among the fungi that cause superficial mycoses. In vitro, clotrimazole exhibits fungistatic and fungicidal activity against isolates of Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, Microsporum canis, Candida spp., and Malassezia pachydermatis. The primary action of clotrimazole is against dividing and growing organisms. Once absorbed through the skin, topical corticosteroids are handled through pharmacokinetic pathways similar to systemically administered corticosteroids.Ĭlotrimazole: Clotrimazole is a broad-spectrum antifungal agent that is used for the treatment of dermal infections caused by various species of dermatophytes and yeast. Inflammation can increase percutaneous absorption. Topical corticosteroids can be absorbed from normal, intact skin. The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the integrity of the epidermal barrier. In a 6-month dermal toxicity study using 0.1% mometasone ointment on healthy intact skin in dogs, systemic effects typical of corticosteroid therapy were noted.
Systemic absorption of mometasone furoate ointment was found to be minimal (2%) over 1 week when applied topically to dogs with intact skin. Mometasone: Mometasone furoate monohydrate is a synthetic adrenocorticoid characterized by a novel (2) furoate 17-ester having chlorine at the 9 and 21 positions, which have shown to possess high topical potency. aeruginosa), coagulase-positive staphylococci, Enterococcus faecalis, Proteus mirabilis and beta-hemolytic streptococci. In clinical trials, gentamicin was shown to have a range of activity against the following organisms commonly isolated from infected canine ears: Pseudomonas spp. In vitro tests have determined that gentamicin is bactericidal and acts by inhibiting normal protein synthesis in susceptible microorganisms. Gentamicin: Gentamicin sulfate is an aminoglycoside antibiotic active against a wide variety of gram-negative and gram-positive bacteria.
DescriptionĮach gram of MOMETAMAX Otic Suspension contains gentamicin sulfate, equivalent to 3 mg gentamicin base mometasone furoate monohydrate equivalent to 1 mg mometasone furoate and 10 mg clotrimazole, in a mineral oil-based system containing a plasticized hydrocarbon gel. Keep this and all drugs out of the reach of children. (GENTAMICIN SULFATE, MOMETASONE FUROATE MONOHYDRATE, AND CLOTRIMAZOLE, OTIC SUSPENSION)ĬAUTION Federal law restricts this drug to use by or on the order of a licensed veterinarian.
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